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. 2019 Apr 11;70(15):3969–3979. doi: 10.1093/jxb/erz166

Fig. 8.

Fig. 8.

Proposed molecular regulatory network for modulation of artemisinin biosynthesis by AaTGA6 in Artemisia annua. AaERF1 directly regulates artemisinin biosynthesis by activating transcription of artemisinin-related genes such as ADS (Yu et al., 2012). AaNPR1 interacts with AaTGA6 and activates transcription of artemisinin-related genes such as AaERF1. AaTGA3 repression of the binding of AaTGA6 to the promoter of AaERF1 may play a feedback-inhibition role in artemisinin biosynthesis. Arrows indicate positive regulation and blocked lines indicate negative regulation; the dashed line indicates an unidentified pathway.