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. 2019 Apr 11;70(15):3969–3979. doi: 10.1093/jxb/erz166

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© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Experimental Biology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 8. — Proposed molecular regulatory network for modulation of artemisinin biosynthesis by AaTGA6 in Artemisia annua. AaERF1 directly regulates artemisinin biosynthesis by activating transcription of artemisinin-related genes such as ADS (Yu et al., 2012). AaNPR1 interacts with AaTGA6 and activates transcription of artemisinin-related genes such as AaERF1. AaTGA3 repression of the binding of AaTGA6 to the promoter of AaERF1 may play a feedback-inhibition role in artemisinin biosynthesis. Arrows indicate positive regulation and blocked lines indicate negative regulation; the dashed line indicates an unidentified pathway.