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Structures of the Compounds Investigated. Common substructure features of aripiprazole and cariprazine are shown in red, those of aripiprazole and brexpiprazole are shown in green. AY9944 is a teratogenic compound used to generated a pharmacological rodent model for Smith-Lemli-Opitz syndrome, trazodone is a commonly prescribed psychoactive piperazine. The piperazine nitrogens are labeled N1 and N2 for purposes of discussion.
