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. Author manuscript; available in PMC: 2019 Aug 7.
Published in final edited form as: Toxicol Appl Pharmacol. 2018 Apr 23;349:21–28. doi: 10.1016/j.taap.2018.04.029

Fig. 2.

Fig. 2.

Cariprazine decreases cholesterol (A) and increases 7-DHC (B) in Neuro2a cells. The effects of cariprazine and brexpiprazole on sterol synthesis were compared to other compounds that inhibit DHCR7. 50 nM of each compound was added to the cell culture medium and cells were exposed in lipid-deficient medium for 48 h. *p < 0.05 and ****p < 0.001 relative to the control conditions.