Table 3.
Univariable and multivariable analysis of enrollment effect on mortality, icu utilization, length of stay and resource utilization.
| Enrolled | Not Enrolled | Unadjusted comparisona (95% CI) | Adjusted comparisona (95% CI)b | p-value | |
|---|---|---|---|---|---|
| Early Mortality (<42 days) | 1 (0.5%) | 5 (3.0%) | 0.14 (0.02, 0.79) | NE | .03c |
| On therapy Mortality (9 mo) | 15 (7.3%) | 15 (8.9%) | 0.76 (0.38, 1.52) | 0.77 (0.41, 1.44) | .40 |
| ICU (yes/no) | 79 (38%) | 61 (36%) | 1.07 (0.81, 1.39) | 1.17 (0.89, 1.52) | .25 |
| Length of Stay | |||||
| Induction I LOSd | 30 (27, 35) | 29 (26, 38) | 0.57 (−6.72, 7.86) | 0.43 (−7.63, 8.51) | .92 |
| On therapy LOSd | 117 (97, 141) | 112 (82, 146) | 5.50 (−3.89, 14.89) | 5.73 (−3.15, 14.61) | .21 |
| ICU LOSe | 3.75 (SD 10) | 4.29 (SD 9.5) | −0.59 (−2.38, 1.19) | −0.12 (−1.98, 1.74) | .90 |
| Resource Utilizationf | |||||
| Antibiotics (5 subclasses) | 100 (96, 105) | 97 (92, 102) | 1.02 (0.97, 1.08) | 1.02 (0.97, 1.09) | .43 |
| Antifungals (3 subclasses) | 71 (68, 75) | 79 (75, 83) | 0.90 (0.85, 0.95) | 0.91 (0.86, 0.97) | .003 |
| Amphotericin | 6 (5, 8) | 8 (6, 10) | 0.82 (0.57, 1.21) | 0.87 (0.59, 1.26) | .46 |
| Echinocandin | 20 (17, 24) | 21 (17, 25) | 1.15 (0.91, 1.45) | 1.19 (0.92, 1.54) | .19 |
| Azole | 45 (41, 49) | 50 (46, 55) | 0.81 (0.74, 0.89) | 0.82 (0.73, 0.91) | .0003 |
| Antivirals | 15 (12, 19) | 17 (13, 22) | 0.85 (0.63, 1.16) | 0.85 (0.59, 1.23) | .40 |
| Antiemetics | 56 (53, 58) | 55 (53, 58) | 1.03 (0.96, 1.10) | 1.05 (0.99, 1.11) | .07 |
| Parenteral Nutrition | 8 (6, 10) | 15 (12, 18) | 0.65 (0.47, 0.91) | 0.72 (0.53, 0.98) | .04 |
| Opiates | 20 (18, 22) | 22 (19, 25) | 0.90 (0.75, 1.08) | 0.90 (0.76, 1.06) | .19 |
| Antihypertensives | 14 (10, 18) | 15 (11, 20) | 0.85 (0.53, 1.34) | 1.05 (0.61, 1.82) | .85 |
| Diuretics | 6 (5, 7) | 10 (8, 12) | 0.61 (0.47, 0.80) | 0.65 (0.46, 0.92) | .01 |
| Oxygen Therapy | 4 (3, 5) | 4 (3, 5) | 0.97 (0.68, 1.37) | 1.00 (0.72, 1.38) | .99 |
| Blood Products | 30 (27, 31) | 30 (28,3 2) | 0.97 (0.89, 1.06) | 0.99 (0.9, 1.08) | .83 |
| G-CSF | 5 (4, 6) | 5 (4, 7) | 0.89 (0.58, 1.36) | 0.89 (0.60, 1.32) | .57 |
a
Risk ratio for morality, ICU; rate ratio for resource use, and mean difference for lengths of stay; Not enrolled is the reference group.
b
Adjusted for race/ethnicity, age, and poverty.
c
p-value for unadjusted comparison as adjusted model had to few events to converge.
d
Median, interquartile range.
e
Mean, standard deviation (SD).
f
Days of use per 100 inpatient days.