Table 3.

Prenatal SRI exposure and child ASD and language outcomes in the current follow-up studies.

Dependent Variable	Mean, SD, Range	R2 Change	β	95% C.I. β	p- Value
Mother-reported Child ASD-related behaviors	166.10, 17.62, 150–240	0.06	0.24	0.07 to 0.48	0.01
Alternate Caregiverreported Child ASD-related behaviors	166.02, 17.18, 150–227	<0.01	0.00	−0.15 to 0.26	0.64
Mother-reported SRS	49.18, 9.56, 35–90	<0.01	0.08	−0.25 to 0.40	0.61
The Autism Diagnostic Observation Schedule (ADOS)	5.64, 4.50, 0–17	0.02	0.14	−0.15 to 0.41	0.31
CASL Pragmatic Language Score	114.36, 14.12, 81–145	0.07	−0.27	−0.53 to −0.01	0.04

Note: All analyses controlled for maternal prenatal depression and child IQ. Mother-reported ASD-related behavior analyses also controlled for child age, and ADOS analyses controlled for child race and Apgar scores. ASD = autism spectrum disorder. SRS = social responsiveness scale. CASL = Comprehensive Assessment of Spoken Language. Child ASD-related behaviors were measured by the CBCL. Missing data were minimal except for the alternative caregiverreported ASD-related behaviors (27% missing), and were handled by listwise deletion. In analyses, CASL was a standardized score, ADOS was the sum total of symptoms, SRS was the sum total of symptoms, and ASD-related behaviors were the sum total of t scores of 3 subscales from the CBCL. Both the maternal and alternative caregiver-reported ASD-related behavior scores were log transformed prior to analyses to reduce skewness and kurtosis.