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. 2019 Aug 7;9:11463. doi: 10.1038/s41598-019-47711-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Selective signals and haplotypes of EPAS1. (A) F_ST values of each SNP between the Tibetan and control populations. The x axis is the physical position on chromosome 3 (Sus scrofa 10.2 build). The region between the two green dashed lines is the candidate sweep. The red box defines the SNPs with the largest genetic differentiation, used to analyze haplotypes. (B) Haplotype pattern of highly differentiated SNPs between the Tibetan and control pig populations using 227 pigs from East Asia and Europe. Each column is a polymorphic genomic location and each row is a phased haplotype. The blue cell represents the ancestor allele and the red cell represents the derived allele. OG: outgroup, TP: Tibetan pigs, CDP: Chinese domestic pig, CWB: Chinese wild boar, EDP: European domestic pig, EWB: European wild boar. (C) The Median-Joining network of haplotypes within EPAS1. Only haplotypes with frequency more than 1 were used to draw the network.