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. 2019 Aug 7;9:11463. doi: 10.1038/s41598-019-47711-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enrichment of variants under different divergence levels and transcription activity assay of alleles in predicted motifs near EPAS1. (A) Enrichment pattern of SNPs at whole genome level. SNPs were divided to different bins by F_ST between Tibetan and lowland pigs. (B) Enrichment pattern of SNPs from selected sweep regions in Tibetan pigs. (C) Selective signals of EPAS1. The black vertical bar in downstream of EPAS1 indicated differentiated SNP positions between Tibetan and lowland pigs. The red dotted line represents top 99% threshold of F_ST at whole-genome level. (D) Predicted motifs with differentiated SNPs in downstream of EPAS1. (E) Transcription activity assay of different alleles within predicted motifs near EPAS1 in pig lung fibroblast cell. AA names of different pGLS3 vectors means ancestral allele and DA means derived allele. (F) Transcription activity assay of different alleles within predicted motifs near EPAS1 in BEAS-2B cell. The two-tailed t test was used for statistical assessment of transcription activity change.