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. 2019 Aug 7;9:11459. doi: 10.1038/s41598-019-48009-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(left) Average interocular differences in refractive error for the experimental and control eyes in each experimental group, normalized to baseline. The early interruption group is represented by black circles, and the late interruption group by squares. The interruption period is indicated with dotted lines. The results from these two treatment groups were compared to treated controls (continuous lens wear, red symbols) and untreated contols (grey symbols). (right) Box plots representing the changes in interocular differences in refractive rate (exp-cont) during the early (T₀ to T₄), and late treatment period (T₄ to T₈) for the different treatment groups: treated controls (red), early interruption (black), late interruption (grey) and untreated control (no color). The interruption periods are indicated by empty symbols. The data shown are mean ± SE.