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. 2019 Aug 7;2:298. doi: 10.1038/s42003-019-0514-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Working model of Piezo1 activation by traction forces. Traction forces (blue arrow) generated by Myosin II motors (yellow and black) along actin filaments (purple) tethered to integrin-based focal adhesion zones (green and tan) generate local increases in membrane tension (depicted by blue region of lipid bilayer and red arrows) that elicit Ca²⁺ flickers from nearby Piezo1 channels (green cylinder in the right part of the figure). Blue dots represent Ca²⁺ ions and dark blue arrow represents Ca²⁺ influx through Piezo1. Piezo1 channels far from force-producing adhesions are not activated (green cylinder in left of figure)