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. 2019 Aug 7;9:11485. doi: 10.1038/s41598-019-47991-y

Table 2.

Data from model dependent mathematical analysis of INH release profiles

Model designation Parameter pH of the release medium
4.4 5.4 6.4 7.4
Zero-order R2 Observed −1.1654 −0.5274 −1.0925 −0.7970
R2 Adjusted −1.1655 −0.5274 −1.0925 −0.7970
First-order R2 Observed 0.8271 0.7938 0.3866 −0.1928
R2 Adjusted 0.8271 0.7938 0.3866 −0.1928
Higuchi R2 Observed 0.7364 0.8673 0.7510 0.8137
R2 Adjusted 0.7364 −0.5274 0.7510 0.8137
Korsmeyer-Peppas R2 Observed 0.9968 0.9949 0.9950 0.9940
R2 Adjusted 0.9964 0.9943 0.9944 0.9932
n 0.3119 0.3518 0.3157 0.3331
Hixson-Crowell R2 Observed 0.6991 0.6439 0.0846 −0.3756
R2 Adjusted 0.6991 0.6439 0.0846 −0.3756
Baker-Lonsdale R2 Observed 0.9812 0.9921 0.9308 0.8844
R2 Adjusted 0.9812 0.9922 0.9308 0.8844

R:2 coefficient of determination. n: diffusion exponent.