Table 3.
Multivariable competing risks regression model using the Fine and Gray method for death from DTC and death from other causes.
| Variables | Death from DTC | Death from other causes | ||||
|---|---|---|---|---|---|---|
| Number of deaths | Subhazard ratio (95% CI) | P value | Number of deaths | Subhazard ratio (95% CI) | P value | |
| Age group | ||||||
| <55 years (n = 1583) | 6 | 1.00 (reference) | 31 | 1.00 (reference) | ||
| 55–65 years (n = 330) | 8 | 4.83 (1.40–16.61) | 0.01 | 26 | 2.69 (1.51–4.81) | <0.01 |
| ≥65 years (n = 157) | 14 | 14.15 (4.08–49.04) | <0.01 | 38 | 6.43 (3.55–11.64) | <0.01 |
| Sex | ||||||
| Female (n = 1751) | 19 | 1.00 (reference) | 72 | 1.00 (reference) | ||
| Male (n = 319) | 9 | 1.38 (0.54–3.52) | 0.50 | 23 | 1.69 (1.06–2.69) | 0.03 |
| T classification | ||||||
| T1 (n = 1436) | 1 | 1.00 (reference) | 49 | 1.00 (reference) | ||
| T2 (n = 278) | 3 | 11.84 (1.22–114.45) | 0.03 | 19 | 1.70 (1.00–2.90) | 0.05 |
| T3 (n = 233) | 4 | 17.98 (1.96–165.08) | 0.01 | 15 | 1.28 (0.72–2.27) | 0.41 |
| T4 (n = 123) | 20 | 85.64 (9.88–742.40) | <0.01 | 12 | 1.28 (0.63–2.57) | 0.49 |
| N classification | ||||||
| N0 (n = 742) | 2 | 1.00 (reference) | 46 | 1.00 (reference) | ||
| N1a (n = 884) | 5 | 4.02 (0.83–19.56) | 0.09 | 23 | 0.62 (0.37–1.05) | 0.07 |
| N1b (n = 444) | 21 | 9.07 (1.97–41.67) | <0.01 | 26 | 1.02 (0.60–1.71) | 0.95 |
| M classification | ||||||
| M0 (n = 2050) | 24 | 1.00 (reference) | 92 | 1.00 (reference) | ||
| M1 (n = 20) | 4 | 5.70 (1.55–21.02) | <0.01 | 3 | 1.60 (0.43–5.93) | 0.48 |
| Number of comorbidities | ||||||
| 0 (n = 1463) | 13 | 1.00 (reference) | 29 | 1.00 (reference) | ||
| 1–2 (n = 574) | 15 | 0.88 (0.37–2.10) | 0.77 | 52 | 2.48 (1.46–4.20) | <0.01 |
| ≥ 3 (n = 33) | 0 | 6.81e-10 (1.87e-10–2.48e-9) | <0.01 | 14 | 9.41 (4.53–19.56) | <0.01 |
Subhazard ratios for death from DTC and death from other causes according to tumor-node-metastasis (TNM) classification and the number of comorbidities were adjusted for age (<55, 55–65, and ≥65 years) and sex. DTC, differentiated thyroid carcinoma; CI, confidential interval. Significant subhazard ratios are indicated in boldface font.