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. 2019 Aug 7;9:11489. doi: 10.1038/s41598-019-47866-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Developmental exposure to TCDD alters gene expression in CD4⁺ T cells following IAV infection. (a) 4-way and (b) 2-way Venn diagrams of differentially expressed genes (DEGs). Comparison groups are as follows: Blue- Vehicle CD44^lo vs. TCDD CD44^lo; Red- Vehicle CD44^lo vs. Vehicle CD44^hi; Green- TCDD CD44^lo vs. TCDD CD44^hi; Yellow- Vehicle CD44^hi vs. TCDD CD44^hi. (c,e) Volcano plots depict DEGs that are down-regulated (green dots) and up-regulated (red dots) by developmental exposure to TCDD in resting (CD44^lo, c) and responding (CD44^hi, e) CD4⁺ T cells compared to vehicle controls. (d,f) For these same comparisons, Ingenuity Pathways Analysis (IPA) was used. Predicted pathways were grouped by cellular function, and pie charts represent the number of pathways that were associated with differentiation, activation, cell cycle/proliferation, survival, migration, metabolism, DNA damage, or epigenetic regulation. The most represented cellular functions are listed in descending order in resting (CD44^lo, d) and responding (CD44^hi, f) CD4⁺ T cells.