Table 1.
Developmental AHR activation affects genes that regulate mitochondrial fission, fusion, and mitophagy.
| Gene | Function | Log2 Fold Change | Adjusted p-value |
|---|---|---|---|
| Fis1 | Promotes fission | 1.07 | 0.0019 |
| Mff | Promotes fission | 1.21 | 0.0075 |
| Cycs | Released following fission | 1.02 | 0.0017 |
| Mfn2 | Promotes fusion | −1.23 | 0.0124 |
| Atg2b | Regulates autophagy/mitophagy | −1.09 | 0.0277 |
| Atg2a | Regulates autophagy/mitophagy | −1.16 | 0.0100 |
| Atg7 | Regulates autophagy/mitophagy | −1.59 | 0.0083 |
DEGs in responding CD4+ T cells and that gene’s function related to mitochondrial fission, fusion, or authophagy/mitophagy are shown. The log2 fold change and adjusted p-value for each gene is listed. An increase in fold change indicates developmental AHR activation increases expression of that gene in CD4+ T cells.