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. 2019 Aug 7;9:11457. doi: 10.1038/s41598-019-47927-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The PEI-absorbed MSN significantly reduced the cytotoxicity of free PEI in PC9 and A549 cells. MP: PEI-absorbed MSN; P: free PEI. The PC9 and A549 cell viability was measured after the treatment of PEI and PEI-absorbed MSN (PEI, 2.25 µg/mL for PC9 cells, 4.5 µg/mL for A549 cells, MSN: 25 µg/mL) for (a) 24 hr and (b) 48 hr. *And **indicates the statistical differences (*p < 0.05 and **p < 0.001) compared with controls.