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. 2019 Jul 10;91(15):9800–9805. doi: 10.1021/acs.analchem.9b01459

Table 1. Examples of Proteins Identified in the Best Sample (Serum +6.9 mg/mL NaCl + FND) That Could Be Detected Neither in the Reference nor with a State-of-the-Art Depletion Column with 64 Antibodies and Their Clinical Relevance.

protein clinical relevance ref
von Willebrand factor Willebrand disease, the most common inherited bleeding disorder (31)
Tetranectin marker for disease activity in patients with rheumatoid arthritis (32)
Proteoglycan 4 diagnostic biomarker for COPD (chronic obstructive pulmonary disease) (33)
Vitamin D-binding protein risk factor for colorectal cancer (34)
Fibulin-1 cardiovascular risk markers in chronic kidney disease and diabetes (35)
Hornerin aberrantly expressed in breast cancer (36)
Hepatocyte growth factor activator diagnostic value for numerous diseases, as well as age and pregnancy (37)
Apolipoprotein M suspected to be a biomarker for certain diabetes types (38)
Endostatin diagnosing malignant pleural effusions, anti angiogenic agent (39)
Suprabasin tumor endothelial cell marker (40)
Angiogenin used in prediction of failure on long-term treatment response and for poor overall survival in non-Hodgkin lymphoma (a certain cancer type) (41)
Desmoplakin biomarker for Creutzfeldt–Jakob disease (42)
Ribonuclease 4 diagnosis of pancreatic cancer (43)