Table 2.
Investigation of the role of TAO in the trypanocidal activity of test compounds.
| Compd | Control s427WT | Control s427WT + 5 mm glycerol | ||
|---|---|---|---|---|
| EC50 [μm][a] | EC50 [μm][a] | RF[b] | p value[c] | |
| 18 | 30.0±0.08 | 31.2±0.6 | 1.04 | n.s. |
| 19 | 16.8±0.06 | 16.3±0.4 | 0.97 | n.s. |
| 20 | 9.2±0.04 | 16.0±0.2 | 1.74 | p<0.001 |
| 22 | 25.4±1.0 | 28.2±0.2 | 1.11 | n.s. |
| SHAM[d] | 86.3±0.4 | 58.9±0.6 | 0.68 | p<0.001 |
[a] Values are the average±SEM of three independent determinations. [b] Resistance factor. [c] Statistical significance was determined using Student's unpaired t‐test; n.s.: not significant. [d] Salicylhydroxamic acid.