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. 2018 Oct 30;234(6):9052–9064. doi: 10.1002/jcp.27583

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© 2018 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Diagrammatic sketch of the working hypothesis. Foxm1 promotes the TGF‐β1‐induced EndMT process in ECs through Smad2/3 signaling pathway and direct binding to and inducing the transcriptional activity of the Snail gene: an EndMT‐promoting transcription factor. ECs: endothelial cells; EndMT: endothelial‐mesenchymal transition; Foxm1: forkhead box M1; Sio A: Siomycin A; TGF‐β, transforming growth factor beta; TGF‐βR: transforming growth factor beta receptor; TSS: transcriptional start site