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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Hum Immunol. 2018 Sep 18;80(6):378–384. doi: 10.1016/j.humimm.2018.09.003

Figure 1:

Figure 1:

Potential routes of antigen entry into the B and T cell zones in the lymph node and spleen. The FRC network guides soluble antigens, dendritic cells and macrophages bearing antigen, as well and T and B cells, into the correct anatomical location to optimize the likelihood of cognate antigen encounter.