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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Hum Immunol. 2018 Sep 18;80(6):378–384. doi: 10.1016/j.humimm.2018.09.003

Figure 2.

Figure 2.

B cell responses in naïve and sensitized recipients, and their control by CTLA-4Ig. Allografts transplanted into naïve recipients elicit a T cell-dependent B cell response that results in a germinal center (GC) reaction, whereas allografts in sensitized recipients elicit a T cell-dependent but GC-independent donor-specific antibody (DSA) response. CTLA-4Ig is inhibitory at multiple stages during primary and recall antibody responses.