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. 2019 Aug 7;13:68. doi: 10.1186/s13036-019-0197-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Nesprin-1 plays a regulatory role in the proliferation, apoptosis, and myogenesis of MSCs. a MSCs were transfected with either LV-siNesprin-1 or LV-GFP and cell apoptosis was analyzed using flow cytometry. Apoptosis was the greatest in the LV-siNesprin-1 MSCs. b Nuclear morphology was observed 72 h after transfection (DAPI). The LIV-siNesprin-1 group exhibited nuclear fusion and fragmentation. c Differentiation of the LIV-siNesprin-1 group was significantly slower than the LV-GFP and Normal groups; majority of the cells remained in the G0/G1 phase of the cell cycle. Adapted and reprinted with permission from [41]