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. 2019 Aug 7;9:63. doi: 10.1186/s13578-019-0326-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Kaplan–Meier survival curves for early-stage NSCLC in relation to miR-7 methylation. X-axis displays the number of months from diagnosis to progression (a, b) or death (c). Y-axis: Probability of PFS (a, b) or OS (c). a Kaplan–Meier survival curve for PFS for MPC cohort (n = 42). The data showed a trend toward increased progression in those with methylated miR-7, but not statistically significant (p = 0.297). b Kaplan–Meier survival curve for PFS for TCGA cohort (n = 795). The PFS of patients with methylated miR-7 was significantly lower (p = 0.010, HR = 0.696). c Kaplan–Meier survival curve for OS for TCGA cohort (n = 879). The graph showed a trend toward increased mortality in miR-7 methylated group. Methylated mirR-7 demonstrated a significantly shorter survival when compared to the patients with unmethylated miR-7 (p = 0.007, HR = 0.894)