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. 2019 Aug 7;9:63. doi: 10.1186/s13578-019-0326-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Kaplan–Meier analysis showing the PFS of adenocarcinoma and squamous carcinoma in patients with methylated NSCLC. (a) Representation of miR-7 methylation status among adenocarcinoma and squamous tumor histologic types, showing that the presence of methylation is more common in adenocarcinoma than in squamous tumor types. (b) Kaplan–Meier survival curve for PFS for TCGA early-stages NSCLC patients harboring miR-7 methylation (n = 523). 370 patients with adenocarcinoma and 153 squamous cell carcinoma. The PFS of patients with adenocarcinoma was significantly lower (p = 0.002)