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. 2019 Aug 7;17:256. doi: 10.1186/s12967-019-2006-0

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The effects of PVN microinjection of saline and TNFα (0.5 ng or 1 ng) on the baseline RSNA and MAP (a, b), and TNFα (1 ng) caused SNA response (the changes of RSNA and MAP) to the pretreatment of TNFα receptor antagonist R-7050 in the PVN. The values are mean ± SD. For each group, n = 6–7; *p < 0.05 versus saline (a, b); ^#p < 0.05 versus Control (a, b); ^&p < 0.05 versus TNFα (0.5 ng a, b); *p < 0.05 versus Saline + Saline (c, d); ^&p < 0.05 versus Control (c, d); ^#p < 0.05 versus Saline + TNFα (c, d). RSNA renal sympathetic nerve activity, MAP mean artery pressure