Table 2.

Co-expression of exhaustion markers

T-cell source	Percentage of T-cells co-expressing LAG-3, PD-1 and Tim-3
	CD4+ T-cells				CD8+ T-cells
	LAG-3/PD-1/Tim-3	LAG-3/PD-1	LAG3/Tim-3	PD-1/Tim-3	LAG-3/PD-1/Tim-3	LAG-3/PD-1	LAG-3/Tim-3	PD-1/Tim-3
Pre	0	0	0.1 (0.07–0.23)	0	0.1 (0.03–0.21)	0	0.1 (0.05–0.29)	0.1 (0.03–0.21)
LS	0.1 (0.07–0.20)	0	0	7.7 (1.66–15.30)	0.2 (0.01–0.61)	0	0.2 (0.12–0.43)	2.0 (1.34–3.44)
HS	0.2 (0.09–0.31)	0	0.1 (0.10–0.21)	6.8 (1.42–10.00)	0.3 (0.14–0.40)	0	0.4 (0.22–0.64)	1.3 (0.90–1.89)

Mean percent and ranges (parentheses) for T-cells from 5 donors are shown. Values less than 0.1% are reported as 0

PRE pre-expansion PBMCs, LS low seed, HS high seed