Table 8.
Effect of perfusion bioreactor with low shear on chondrocyte proliferation and matrix composition
| Pa | RPM | Rate | Cell proliferation | Collagen | GAG | Proteoglycan | Scaffold | Bioreactor | |
|---|---|---|---|---|---|---|---|---|---|
| [46–49] | 1.10 | – | 0.5–2 | Chondrocyte | Increase | Increase | Increase | Alginate | Perfusion |
| [50] | – | 15–30 | – | Chondrocyte | Increase | Increase | Increase | Hyaluronan benzyl ester non-woven | Rotating |
| [51] | – | – | – | No cell | Increase 33% | Increase 68% | Not measured | No scaffolds | Rotating |
| [52] | – | – | – | Chondrocyte | Increase 39% | increase 95% | – | No scaffolds | - |
| [53] | 17 kPa | 1.32 ml h−1 | Chondrocyte | Increase | Increase | Increase | Scaffold-free | acoustofluidic perfusion |