Table 2.
Screening visit and informed consent | |
- Informational session about study requirements | |
- Obtain informed consent | |
- Verify inclusion criteria (i.e., BMI and blood pressure) | |
- Physical exam/review of medications | |
- Non-exercise physical activity via activPAL | |
- Exercise calendar and Barriers screening forms | |
- Complete metabolic panel, lipids, insulin, C-reactive protein, and blood chemistries | |
Baseline | |
- PWV, muscle biopsy, IVGTT, and NIRS | |
- SF-36 and FFQ | |
- Body weight, blood pressure, anthropometry, DEXA, and maximal exercise test | |
Randomization | |
- CON, MOD-INT, or HIGH-INT group | |
Mid-intervention (12 weeks) | |
- Waist circumference | |
- Body weight | |
- Maximal exercise test | |
Follow-up (24 weeks) | |
- Non-exercise physical activity via activPAL | |
- PWV, muscle biopsy, IVGTT, and NIRS | |
- SF-36 and FFQ | |
- Complete metabolic panel, lipids, insulin, C-reactive protein, and blood chemistries | |
- Body weight, blood pressure, anthropometry, DEXA, and maximal exercise test |
Abbreviations: BMI body mass index, CON non-exercise control (group), DEXA dual-energy x-ray absorptiometry, FFQ food frequency questionnaire, HIGH-INT high-intensity exercise (group), IVGTT intravenous glucose tolerance test, MOD-INT moderate-intensity exercise (group), NIRS near-infrared spectroscopy, PWV pulse wave velocity, SF-36 short-form health survey