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. 2019 Aug 8;19:789. doi: 10.1186/s12885-019-6002-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effects of FAT4 silencing on liver cancer cell growth and proliferation. (a) Confirmation on the efficiency of FAT4 silencing by assessing the mRNA and protein expression levels after siRNA transfection at 24 h and 48 h, respectively. (b) siRNA knockdown of FAT4 significantly increased cell proliferation compared with cells transfected with control siRNA at 48 and 72 h. (c) Significantly increased in cell growth was observed in cells transfected with FAT4 siRNA at 48 and 72 h after transfection. (d) Representative morphological appearance of SNU-387 cells treated with FAT4 siRNA by phase contrast microscopy at 24, 48, 72 h (40× magnification). Arrows indicate rapidly proliferating cell clumps. Data are mean values ± SEM of triplicate determinations (*P < 0.01 and ***P < 0.0001)