Table 2.

Comprehensive genomic profiling by FoundationOne™

Patient	TMB	Genomic Findings
4	15 muts/mb	CDKN2A/B loss CHEK2 R117G DNMT3A R771 FANCD2 E118 MLL3 splice site 2533-1G > A TP53 L145R, splice site 673-1G > A
5	12 muts/mb	CRKL amplification DNMT3A R635W – subclonal MAPK1 amplification SF3B1 K700E – subclonal ZRSR2 splice site 121 + 2 T > G