Fig. 2.

NR1B2 were down-regulated in clinical samples and predicts poor clinical outcome. a. NR1B2 expression in 16 paired KIRC and non-tumor tissue were evaluated by quantitative real-time polymerase chain reaction. b. Western blots detected the NR1B2 protein in tumor tissues(T) and paired adjacent non-tumor tissues(N) from 16 KIRC patients. c. Representative TMA images showing NR1B2 staining in non-tumor tissues(N) and KRIC (T) sections. d. The statistics of NR1B2 score in 141 TMA cohort. e. Relative expression levels of NR1B2 in TMA cohort with tumor stage, lymph node invasion and metastasis status. f. Kaplan-Meier survival curve of TMA cohort with low (n = 77) and high (n = 64) NR1B2 expression. g-h. Univariate (g) and multivariate(h) analysis of the hazard ratios (HRs) showed that the down-regulation of NR1B2 may be an independent prognostic factor for the overall survival rate in our TMA cohort. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001