Fig. 4.
Atorvastatin prevents aldosterone-induced ROS generation via Rac1/2 in WKY VSMCs. Effects of aldosterone (10−7 mol/L) on ROS generation measured by lucigenin chemiluminescence assay in the absence and presence of EHT1864 (10−6 mol/L) or tiron (10−5 mol/L) (30 minute-incubation). Results are mean ± SEM of 5–6 experiments. *P < 0.05, vs. vehicle.