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. Author manuscript; available in PMC: 2019 Aug 8.
Published in final edited form as: Am J Surg Pathol. 2019 Jan;43(1):121–131. doi: 10.1097/PAS.0000000000001170

Figure 5.

Figure 5.

FACETS analysis in 4 cases. The integer copy number (copy number call corrected for tumor purity and ploidy) is plotted on the y-axis. Diploid corresponds to n = 2. Chromosomes 1–22 are plotted on the x-axis. Black line - total copy number, red line - minor allele. (A-B) Cases 4 (A) and 5 (B) (MTOR p.L2427R) show recurrent chromosome 1 loss (solid box). (C-D) Cases 2 (C) and 6 (D) (biallelic TSC2 mutations) have no shared gains/losses. Dashed boxes in (C) mark copy number changes detected in minor clone(s) with an estimated clone fraction ≤ 9%.