FIG. 4.

Experimental Analysis of a Failure Mode. (A) Conceptual representation of the path by which the “channel capture” failure mode may occur during initialization of reactor rotation. (B) Experimental validation: The panel shows the incidence of channel capture of human dermal fibroblasts cultured for 24 h. (C) Representative images of A549 aggregates of aggregates taken from the channel volume of the novel bioreactor after 72 h in culture. Scale bar for (C) is 200 μm. Color images are available online.