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. 2018 Oct 6;29(9):3676–3686. doi: 10.1093/cercor/bhy247

Figure 3.

Figure 3.

Exposure to amphetamine in early adolescence, but not mid-adolescence or adulthood, leads to blunted PFC dopamine turnover in adulthood. (A) Mice that received amphetamine during early adolescence have reduced baseline HVA content in the PFC. Dopamine turnover, as assessed by the ratio of HVA/dopamine content, is significantly reduced in adult mice that received amphetamine in early adolescence. (B) Baseline dopamine and HVA content are not altered in adult mice that received amphetamine during mid-adolescence. There are no significant changes in dopamine turnover in the PFC of mice that received amphetamine in mid-adolescence. (C) Baseline dopamine and HVA content are not altered in adult mice that received amphetamine during adulthood. There are no significant changes in dopamine turnover in the PFC of mice that received amphetamine in adulthood.