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. 2018 Oct 1;29(9):3651–3665. doi: 10.1093/cercor/bhy244

Figure 5.

Figure 5.

Main effect of sex and age*sex interaction on hippocampal shape. (A) Significant F > M clusters and peaks for the main effect of sex extracted from the t-map using a corrected P < 0.05 threshold when controlling for age, scanner type, and study. On the left surface, a cluster on the lateral body, t(1674) = 8.20, P < 0.001, d = 0.4, and mesial body, t(1674) = 6.12, P < 0.001, d = 0.3, reached statistical significance. On the right surface, clusters located on the lateral edge, t(1674) = 8.68, P < 0.001, d = 0.42, medial edge, t(1674) = 6.76, P < 0.001, d = 0.33, and head, t(1674) = 5.04, P < 0.001, d = 0.25, reached significance. (B) Significant age*sex interaction on adjusted hippocampal volume is observed on the superior posterior lateral body of the left hippocampal surface when controlling for scanner type and study. ROI analysis of the significant cluster shows the average adjusted RD regressed against age and stratified by sex. Females show a significant and positive relationship with age, b = 0.018, t(847) = 5.97, P < 0.001, while males do not, b = 0.0002, t(824) = 0.37, P = 0.71. A corrected P < 0.05 threshold was applied to obtain the P-value surface maps.