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. 2019 Jun 10;3(3):pkz038. doi: 10.1093/jncics/pkz038

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com.

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Figure 5. — Site- and stage-specific cancer incidence trends for 25- to 39-year-old women and men based on the annual percent change (APC) after the most recent joinpoint inflection point, Surveillance, Epidemiology, and End Results 9 database registries, 1975–2015. APCs are based on the time trend after the most recent inflection point identified by joinpoint regression using data for all stages combined. Refer to Figures 3 and 4 for the year of the most recent inflection point for each cancer. Incidence rates are age-adjusted to the 2000 US standard population. Cancer types are classified based on SEER’s site recode International Classification of Diseases for Oncology, third revision/World Health Organization-2008 variable: kidney = kidney and renal pelvis; liver = liver and intrahepatic bile duct; oral = oral cavity and pharynx; uterine = corpus and uterus, NOS. Positive APCs, which indicate increasing incidence over time, are in red (color shading darkens with increasing values); negative APCs, which indicate decreasing incidence over time, are in blue. Statistically significant APCs (H0: APC = 0; P < .05 for a two-sided test based on the t distribution) are bold. CI = confidence interval.