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. Author manuscript; available in PMC: 2019 Sep 6.
Published in final edited form as: Nat Med. 2019 Mar 6;25(3):487–495. doi: 10.1038/s41591-019-0381-y

Extended Data Figure 10 |. Clinical associations of iMM-AGE scores in the Framingham Heart Study dataset.

Extended Data Figure 10 |

a, Expression levels of genes used for IMM-AGE approximation in gene expression samples of Framingham Heart Study participants ordered by approximated IMM-AGE scores. b, Correlation of estimated IMM-AGE scores with age and gender (linear regression P = 7×10−63 and 7.22 ×10−27 (n = 2,292) for age and gender, respectively). Points correspond to individuals; color denotes gender. c, Age- and gender-adjusted IMM-AGE score of individuals stratified based on cardiovascular disease (dots); bold lines denote mean values (P= 0.0023, n = 2,292, two-tailed f-test). d, IMM-AGE score association with cardiovascular risk factors as obtained by linear regression. Bar colors denote positive (light blue) or negative (dark blue) associations. e, Linear regression of IMM-AGE versus DNA methylation age, where both variables were adjusted for cardiovascular risk factors and cardiovascular disease (n = 2,139 individuals). **P<0.01; CVD, cardiovascular disease.