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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Circ Heart Fail. 2019 Jun 21;12(7):e006125. doi: 10.1161/CIRCHEARTFAILURE.119.006125

TABLE 2.

Crude and Adjusted Hazard Ratios for Efficacy Outcomes by Time-Updated Total Number of Physical Exam Signs

Outcomes Hazard ratio (95% CI) per sign increase P-value
Composite endpoint
   Crude model 1.61 (1.41, 1.81) <0.001
   Multivariable-adjustment model 1.45 (1.28, 1.63) <0.001
Cardiovascular mortality
   Crude model 1.52 (1.28, 1.80) <0.001
   Multivariable-adjustment model 1.41 (1.18, 1.68) <0.001
Heart failure hospitalization
   Crude model 1.77 (1.56, 2.01) <0.001
   Multivariable-adjustment model 1.57 (1.37, 1.80) <0.001
All cause mortality
   Crude model 1.43 (1.25, 1.63) <0.001
   Multivariable-adjustment model 1.34 (1.17, 1.53) <0.001

HR, hazard ratio; CI, confidence interval.

Multivariable model adjusted for New York Heart Association class, diabetes mellitus, serum creatinine, heart rate, age, sex, white race, current smoking, atrial fibrillation, peripheral artery disease, ejection fraction, and randomization arm.