TABLE 3.
Between Treatment Analysis of Change in Physical Exam Sign Frequency at 4 Month
| Placebo N=727 |
Spironolactone N=735 |
Between Group Difference (95% CI)* |
Odds Ratio (95% CI)* |
P-value* | |
|---|---|---|---|---|---|
| Average number of physical exam signs | 0.65 ± 0.70 | 0.54 ± 0.65 | −0.10 (−0.16, −0.03) | − | 0.005 |
| Frequency of physical exam signs, n (%) | 0.007 | ||||
| 0 | 345 (47.5%) | 398 (54.2%) | − | − | |
| 1 | 303 (41.7%) | 281 (38.2%) | − | − | |
| 2 | 70 (9.6%) | 51 (6.9%) | − | − | |
| 3 | 9 (1.2%) | 5 (0.7%) | − | − | |
| Jugular venous distention, n (%) | 75 (10.2%) | 48 (6.5%) | − | 0.60 (0.41, 0.88) | 0.01 |
| Edema, n (%) | 369 (48.7%) | 319 (42.1%) | − | 0.74 (0.60, 0.92) | 0.006 |
| Rales, n (%) | 49 (6.6%) | 48 (6.4%) | − | 1.06 (0.69, 1.61) | 0.80 |
*
Adjusted for baseline exam.