TABLE 4.

Relationship between Reducing Congestion and Quality of Life at the 4-Month Visit.

	Change in Quality of Life Score Minimally-adjusted Model Beta-coefficient (95% CI)*	P-value	Change in Quality of Life Score Fully-adjusted Model Beta-coefficient (95% CI)*†	P-value
	KCCQ-OSS
Total number of physical exam signs	4.4 (3.0, 5.7)	<0.001	4.0 (2.4, 5.6)	<0.001
Edema	3.9 (1.8, 5.9)	<0.001	4.4 (1.9, 6.9)	<0.001
Jugular venous distention	6.5 (2.7, 10.3)	0.001	6.0 (1.7, 10.2)	0.006
Rales	4.7 (0.5, 8.9)	0.029	3.0 (−2.0, 7.9)	0.24
	EQ5D-VAS
Total number of physical exam signs	2.7 (1.4, 4.1)	<0.001	2.4 (0.7, 4.0)	0.004
Edema	3.3 (1.5, 5.2)	<0.001	2.8 (0.5, 5.0)	0.015
Jugular venous distention	3.9 (0.5, 7.3)	0.026	3.9 (0.1, 7.8)	0.044
Rales	2.0 (−1.8, 5.7)	0.30	0.5 (−3.9, 4.9)	0.82

CI, confidence interval; KCCQ-OSS, Kansas City Cardiomyopathy Questionnaire Overall Summary Score; EQ5D-VAS, EQ5D visual analog scale.

^*Expressed per decrease in, or absence of, physical exam sign. All analyses controlled for randomization arm and baseline physical exam.

^†Additionally adjusted for serum creatinine, systolic blood pressure, diastolic blood pressure, diabetes mellitus, atrial fibrillation on electrocardiogram, body mass index, and heart rate.