TABLE 5.

Prognostic Value of Time-Updated Signs and Baseline Signs after Minimal and Fully Adjusted Cox Regression

Outcomes	Minimally-adjusted Model HR (95% CI)*	P-value	Fully-adjusted Model HR (95% CI)†	P-value	Baseline sign × time-updated signs interaction P-value†
Composite endpoint
Time-updated signs	1.57 (1.38, 1.77)	<0.001	1.43 (1.26, 1.62)	<0.001	0.62
Baseline signs	1.08 (0.96, 1.23)	0.21	1.05 (0.92, 1.19)	0.50
Cardiovascular mortality
Time-updated signs	1.53 (1.28, 1.84)	<0.001	1.43 (1.18, 1.72)	<0.001	0.46
Baseline signs	0.96 (0.79, 1.17)	0.70	0.95 (0.78, 1.16)	0.64
HF hospitalization
Time-updated signs	1.71 (1.49, 1.97)	<0.001	1.55 (1.34, 1.79)	<0.001	0.82
Baseline signs	1.09 (0.95, 1.26)	0.25	1.04 (0.90, 1.21)	0.59
All cause mortality
Time-updated signs	1.44 (1.25, 1.65)	<0.001	1.35 (1.17, 1.55)	<0.001	0.02
Baseline signs	0.99 (0.85, 1.14)	0.84	0.98 (0.84, 1.14)	0.76

HF, heart failure; CI, confidence interval;

Baseline signs do not predict adverse events when simultaneously adjusted for time-updated signs of congestion.

^*Adjusted simultaneously for time-updated and baseline number of signs of congestion.

^†Additionally adjusted for New York Heart Association class, diabetes mellitus, serum creatinine, heart rate, age, white race, current smoking, atrial fibrillation, peripheral artery disease, ejection fraction, randomization arm, and sex.