Table 3.

Cox regression models with hazard ratios (HRs) and 95% confidence interval (95% CI) for the association between gout and mortality, as well as incident congestive heart failure (CHF), ischemic stroke (IS) and dementia.

	Mortality		Incident CHF		Incident IS		Incident Dementia
	Full Model	CHA2DS2-VASc model	Full Model	CHA2DS2-VASc model	Full Model	CHA2DS2-VASc model	Full Model	CHA2DS2-VASc model
Gout	0.92 (0.82–1.03)	0.98 (0.88–1.09)	1.21 (1.00–1.47)	1.25 (1.04–1.51)	0.64 (0.49–0.82)	0.50 (0.39–0.64)	0.79 (0.58–1.08)	0.64 (0.48–0.86)
Harrell’s C without gout	0.7488	0.7541	0.6926	0.6679	0.6650	0.6172	0.7556	0.7387
Harrell’s C with gout included	0.7490	0.7541	0.6940	0.6690	0.6679	0.6279	0.7563	0.7414
Model improvement with gout	0.0002	0.0000	0.0014	0.0011	0.0029	0.0107	0.0007	0.0027

Fully adjusted models (age, sex, socio-economic variables, co-morbidity, anticoagulant treatment) and models adjusted for CHA2DS2-VASc (with age and sex included) are shown. Bold values are statistically significant for HRs, or exceeding 0.01 in model improvement for Harrell’s