Table 2.
Estimates of from the GRE approach, LDSC (in-sample), S-LDSC (baseline-LD/in-sample), and SumHer (in-sample) for 22 complex traits and diseases in the UK Biobank (N = 290K unrelated British individuals, M = 460K typed SNPs).
Trait | GRE | S.E. | LDSC | S.E. | S-LDSC | S.E. | SumHer | S.E. |
---|---|---|---|---|---|---|---|---|
Smoking Status | 0.122 | 3.90E-03 | 0.178 | 7.70E-03 | 0.110 | 8.50E-03 | 0.132 | 4.30E-03 |
Height | 0.602 | 4.70E-03 | 0.730 | 2.70E-02 | 0.555 | 3.10E-02 | 0.634 | 2.70E-02 |
BMI | 0.285 | 4.20E-03 | 0.436 | 1.20E-02 | 0.289 | 1.70E-02 | 0.315 | 9.00E-03 |
WHR | 0.173 | 4.00E-03 | 0.256 | 1.20E-02 | 0.184 | 1.60E-02 | 0.198 | 9.40E-03 |
Systolic Blood Pressure | 0.159 | 4.20E-03 | 0.243 | 9.00E-03 | 0.134 | 9.70E-03 | 0.177 | 5.70E-03 |
Diastolic Blood Pressure | 0.154 | 4.20E-03 | 0.233 | 8.60E-03 | 0.130 | 9.70E-03 | 0.170 | 6.40E-03 |
Eczema | 0.116 | 4.20E-03 | 0.165 | 1.10E-02 | 0.107 | 1.20E-02 | 0.130 | 8.80E-03 |
Asthma | 0.116 | 4.90E-03 | 0.163 | 1.20E-02 | 0.116 | 1.70E-02 | 0.131 | 1.20E-02 |
Hypertension | 0.162 | 4.00E-03 | 0.244 | 9.40E-03 | 0.142 | 1.10E-02 | 0.180 | 6.10E-03 |
High Cholesterol | 0.082 | 5.10E-03 | 0.127 | 1.30E-02 | 0.138 | 5.80E-02 | 0.088 | 8.30E-03 |
Diabetes (Any) | 0.070 | 3.70E-03 | 0.093 | 5.90E-03 | 0.062 | 8.70E-03 | 0.074 | 5.00E-03 |
Type 2 Diabetes | 0.071 | 3.80E-03 | 0.090 | 6.10E-03 | 0.057 | 8.80E-03 | 0.071 | 4.00E-03 |
Hypothyroidism | 0.088 | 5.20E-03 | 0.142 | 1.30E-02 | 0.078 | 1.20E-02 | 0.110 | 1.70E-02 |
Thyroid Disorders | 0.084 | 5.20E-03 | 0.141 | 1.30E-02 | 0.080 | 1.20E-02 | 0.110 | 2.00E-02 |
Endocrinopathies | 0.069 | 5.10E-03 | 0.084 | 7.00E-03 | 0.058 | 9.90E-03 | 0.068 | 5.00E-03 |
Cardiovascular Diseases | 0.143 | 5.30E-03 | 0.228 | 1.10E-02 | 0.140 | 1.40E-02 | 0.164 | 6.00E-03 |
Respiratory and ENT Diseases | 0.086 | 5.20E-03 | 0.120 | 1.20E-02 | 0.079 | 1.40E-02 | 0.090 | 9.50E-03 |
Psoriasis | 0.019 | 5.00E-03 | 0.071 | 3.10E-02 | 0.035 | 1.20E-02 | 0.059 | 4.20E-02 |
Dermatologic Disorders | 0.023 | 5.00E-03 | 0.049 | 1.40E-02 | 0.034 | 9.90E-03 | 0.031 | 1.10E-02 |
Rheumatoid Arthritis | 0.008 | 5.00E-03 | 0.041 | 2.10E-02 | 0.010 | 7.90E-03 | 0.021 | 1.20E-02 |
Autoimmune Disorders (Broad) | 0.063 | 5.10E-03 | 0.105 | 1.20E-02 | 0.050 | 9.50E-03 | 0.079 | 1.70E-02 |
Autoimmune Disorders (Certain) | 0.015 | 5.00E-03 | 0.052 | 2.60E-02 | 0.005 | 7.60E-03 | 0.047 | 3.40E-02 |