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. 2019 Jul 1;9(8):2637–2646. doi: 10.1534/g3.119.400232

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Copyright © 2019 Zeiss et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cardiac histopathology in animals 6 weeks (acute) and 12 weeks (chronic) after initiating doxorubicin (Dox) treatment (25mg/kg total cumulative dose, acute). Intracytoplasmic vacuolation typical of doxorubicin toxicity (black arrows, A and inset), accompanied by rare myofiber atrophy (white arrow, A) prevailed in acutely intoxicated mice. In the chronic phase (B), pathology was dominated by areas of disorganization with marked variation in myofiber diameter, myofiber vacuolation in some animals (black arrows), and fine chicken-wire like fibrosis (white arrows, C and inset, Sirius Red). Atrial pathology was accompanied in some cases by atrial thrombosis (C). Atrial lesions were characterized by myofiber vacuolation (white arrows, D), myofiber atrophy/loss, and lymphohistiocytic inflammation (black arrows, D). Atrial lesions (illustrated in an acute phase animal in C) were more severe in the chronic phase. Hematoxylin and eosin (A, D); Sirius Red staining (inset, B). Bar = 50µm (A, B, inset B, D); 20µm (inset A); 200 µm (C).