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. 2019 Mar 18;2019(12):2289–2296. doi: 10.1002/ejoc.201900059

Scheme 1.

Scheme 1

A) Synthesis of (–)‐trans‐Δ8‐THC using (–)‐verbenol (2) and olivetol (1a) by Mechoulam et al.;9 B) Synthesis of (–)‐trans‐Δ9‐THC‐Br using multistep synthesis by Carreira et al.;10 C) Our revised modular synthesis of (–)‐trans‐Δ8‐THC derivatives.