Table 3. Association Between the Hyperinflammation and Immunosuppression and Normal Phenotypes and Long-term Outcomes.
| Variables | No. of Events/No. at Risk (%) | Adjusted OR, HR, or SHR (95% CI)a | P Value | |
|---|---|---|---|---|
| Hyperinflammation and Immunosuppression Phenotype | Normal Phenotype | |||
| All-cause 1-y mortality | 77/326 (23.4) | 6/141 (4.3) | 8.26 (3.45-21.69) | <.001 |
| All-cause readmission or death, d | ||||
| 0-180 | 144/326 (44.2) | 48/141 (34.0) | 1.53 (1.10-2.13) | .01 |
| 181-365 | 30/182 (16.5) | 15/93 (16.1) | 1.18 (0.64-2.20) | .59 |
| Readmission or death due to infection, d | ||||
| 0-180 | 79/326 (24.2) | 27/141 (19.1) | 1.35 (0.87-2.10) | .18 |
| 181-365 | 22/217 (10.1) | 5/114 (4.5) | 2.00 (0.75-5.36) | .17 |
| Readmission or death due to cardiovascular disease, d | ||||
| 0-180 | 22/326 (6.7) | 2/141 (1.4) | 5.07 (1.18-21.84) | .02 |
| 180-365 | 6/258 (2.3) | 7/139 (5.0) | 0.42 (0.14-1.28) | .13 |
| Readmission or death due to cancer, d | ||||
| 0-180 | 25/326 (7.7) | 2/141 (1.4) | 5.15 (1.25-21.18) | .02 |
| 180-365 | 7/269 (2.6) | 5/139 (3.6) | 0.67 (0.20-2.27) | .53 |
Abbreviations: HR, hazard ratio; OR, odds ratio; SHR, subdistribution hazard ratio.
a
The ORs were estimated using logistic regression model for all-cause 1-year mortality. The HRs were estimated using a Cox proportional hazards regression model for all-cause 1-year readmission or death. The SHRs were estimated using the Fine-Gray model for cause-specific analyses of death or readmission. Covariates included age, sex, race/ethnicity, Charlson Comorbidity Index score, APACHE II score, infection site, mechanical ventilatory support, vasopressor use, and dialysis.