Table 3.

Trend changes in antimicrobial resistance of Escherichia coli to carbapenems and fluoroquinolones from 2011 to 2016

Antibiotic	Resistance rate (%), by year						Time series analysis
	2011	2012	2013	2014	2015	2016	Trend	β	P value
Imipenem	0	0	0.1	0.4	0.5	1.5	Increasing	0.2657	0.0239
Meropenem	0	0	0	0.3	0.3	1.3	Increasing	0.2200	0.0471
Levofloxacin	61.3	61.3	59.1	57.7	55.5	53.9	Decreasing	−1.6191	0.0013
Ciprofloxacin	64.3	64.3	61.2	61.4	58.7	58.2	Decreasing	−1.4038	0.0002