. 2019 Aug 8;14(8):e0220871. doi: 10.1371/journal.pone.0220871

Table 4. Downregulated proteins in ICL-M-treated P. falciparum 3D7.

Biological Process	NCBI Accession Number	Protein Description	Protein Mass	PI	Protein Score	Percent Coverage	Localization
Cell Rescue Defence	gi\|23499261\|	1-cys peroxiredoxin	25148	6.31	155	47.3	Cytoplasm
	gi\|23615654\|	Thioredoxin-related protein, putative	23972	9.44	134	26.9	Membrane
Cytoskeleton	gi\|23504938\|	Alpha tubulin 1	50264	4.93	234	23.8	Cytoplasm
	gi\|23504954\|	Dynein heavy chain, putative	720134	6.18	32	10.6	Cytoplasm
Invasion	gi\|23504955\|	High molecular weight rhoptry protein 3	104789	6.25	150	21.4	Rhoptry
Metabolism	gi\|237640532\|	HAP protein	37376	4.97	141	32.2	Food Vacuole
	gi\|46361188\|	Hexokinase	55226	6.72	53	31.2	Cytoplasm
	gi\|23504543\|	Small ubiquitin-related modifier	11053	4.74	52	38	Nucleus
Protein degradation	gi\|124804234\|	Autophagy-related protein 7, putative	156530	6.05	29	18.2	Cytoplasm
Translation	gi\|23504556\|	60S ribosomal protein L4	46183	10.5	268	34.3	Cytoplasm
	gi\|23615172\|	40S ribosomal protein S7, putative	22467	9.81	266	41.8	Cytoplasm
	gi\|23615526\|	60S ribosomal protein L6-2, putative	25516	10.1	222	26.7	Cytoplasm
	gi\|225631740\|	60S ribosomal protein L19	21566	11.32	168	14.3	Cytoplasm
	gi\|23499154\|	60S ribosomal protein L13-2, putative	25425	10.78	123	30.2	Cytoplasm
	gi\|124802670\|	60S ribosomal protein L3	44193	10.21	89	29.3	Cytoplasm
	gi\|4494003\|	40S ribosomal protein S3A, putative	30028	9.8	55	33.2	Cytoplasm
	gi\|23504862\|	Eukaryotic translation initiation factor 3 subunit E, putative	61379	7.08	49	23.4	Cytoplasm
	gi\|258597702\|	40S ribosomal protein S25	11656	10.12	44	55.2	Cytoplasm
	gi\|23498839\|	Eukaryotic translation initiation factor 3 subunit I, putative	37261	6.43	36	19.6	Cytoplasm
	gi\|124804772\|	60S ribosomal protein L35ae, putative	16255	10.55	25	26.4	Cytoplasm
	gi\|23498787\|	60S ribosomal protein L34	17340	10.77	24	10.7	Cytoplasm
Trafficking	gi\|23498233\|	Small GTP-binding protein sar1	22006	6.75	72	31.3	Endoplasmic Reticulum
	gi\|13375179\|	Putative GTPase	22872	6.18	47	16	Membrane
	gi\|23615179\|	Sodium/hydrogen exchanger, Na+, H+ antiporter	225940	8.68	29	11.4	Membrane
Unknown	gi\|8247298\|	Hypothetical protein, partial	4755	9.23	159	60	Unknown
	gi\|124801947\|	RNA-binding protein, putative	30033	10.07	55	35.1	Unknown
	gi\|23504857\|	Hsc70-interacting protein	51092	4.67	45	14.6	Unknown
	gi\|225632182\|	Conserved Plasmodium protein, unknown function	126994	5.28	39	12	Unknown
	gi\|23498915\|	Conserved Plasmodium protein, unknown function	36570	8.79	39	22	Unknown
	gi\|225632293\|	Plasmodium exported protein, unknown function	36390	5.74	35	22.2	Unknown
	gi\|14530178\|	Krueppel-like protein	151550	7.89	33	11.5	Membrane
	gi\|23498950\|	Zinc finger, C3HC4 type, putative	253816	8.32	32	15.5	Unknown
	gi\|23615182\|	Conserved Plasmodium protein, unknown function	1111079	9.12	30	15.6	Membrane
	gi\|23504877\|	Conserved Plasmodium protein, unknown function	225390	6.01	30	16	Unknown
	gi\|3649757\|	Conserved Plasmodium protein, unknown function	202018	8.3	29	16.5	Cytoplasm
	gi\|225631936\|	MORN repeat protein, putative	519893	9.15	29	10.3	Membrane
	gi\|124808756\|	Conserved Plasmodium protein, unknown function	192484	9.67	29	16.8	Membrane
	gi\|124806636\|	Conserved Plasmodium protein, unknown function	212627	4.96	29	12.8	Unknown
	gi\|23504575\|	Conserved Plasmodium protein, unknown function	369953	5.29	29	9	Unknown
	gi\|124809084\|	Conserved Plasmodium protein, unknown function	152167	8.42	29	12.9	Unknown
	gi\|124805631\|	Conserved Plasmodium protein, unknown function	208541	8.3	29	15.2	Unknown
	gi\|124802600\|	Conserved Plasmodium protein, unknown function	190279	8.29	29	10.9	Unknown
	gi\|124804432\|	Conserved Plasmodium protein, unknown function	133324	5.18	29	17.4	Unknown
	gi\|124804384\|	Conserved Plasmodium protein, unknown function	118257	8.84	29	14.6	Unknown
	gi\|225632254\|	rRNA-processing protein FCF1, putative	23145	9.63	29	23.2	Nucleus
	gi\|23505139\|	RNA-binding protein, putative	22965	9.51	27	20.3	Unknown
	gi\|124808373\|	Conserved Plasmodium protein, unknown function	390446	9.23	25	11.7	Unknown
	gi\|23615433\|	Conserved Plasmodium protein, unknown function	319935	7.32	25	15.5	Unknown
	gi\|23498752\|	Conserved Plasmodium protein, unknown function	118270	8.1	23	9	Unknown
	gi\|225631798\|	Conserved protein, unknown function	296598	9.02	22	15.4	Membrane
	gi\|124804419\|	Conserved Plasmodium protein, unknown function	330099	6.16	21	12.1	Unknown
	gi\|225631940\|	Conserved Plasmodium protein, unknown function	737235	9.13	21	11.3	Membrane
	gi\|124804142\|	Leucine-rich repeat protein	93275	8.97	18	13.9	Unknown
	gi\|225631849\|	Conserved Plasmodium protein, unknown function	102515	8.83	18	11.7	Unknown