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. 2019 Aug 8;14(8):e0220860. doi: 10.1371/journal.pone.0220860

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© 2019 Li et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — (A) Photographs at 0 and 24h after wounding demonstrated that CRISPR-Cas9 mediated CD133^knockout cells showed significantly decreased wound healing rate compared to the control (***P<0.001). (B) CD133^knockout cells had the least average number of migrating cells among the three groups in transwell migration assay (***P<0.001). (C) In transwell invasion assay, the average number of invasive cells in CD133^knockout group was 11.67 and control cells were 32.33 and 29.67, respectively (***P<0.001).