| 1. Symptoms of esophageal dysfunction |
| ○ Concomitant atopic conditions should increase suspicion for EoE |
| ○ Endoscopic findings characteristic of EoE should increase suspicion |
| 2. Biopsy findings of 15 eosinophils per high-power field (approximately 60 eosinophils/mm2), with tissue eosinophilia isolated to the esophagus |
| 3. Other causes of esophageal eosinophilia have been ruled out, for example: eosinophilic gastrointestinal disease with esophageal involvement; achalasia and other disorders of esophageal dysmotility; Hypereosinophilic syndrome; Crohn disease with esophageal involvement; infections (fungal, viral); connective tissue disorders; dermatologic conditions with esophageal involvement (ie: pemphigus); drug hypersensitivity reactions; pill esophagitis; graft vs host disease; Mendelian disorders (Marfan syndrome type II, hyper-IgE syndrome, PTEN hamartoma tumor syndrome, Netherton syndrome, severe atopy metabolic wasting syndrome) |
