Table 2.
Demographic characteristics and clinical history among two groups, the LIT and No LIT groups.
| Variables | All (n = 1096) |
LIT Group (n = 752) |
No LIT Group (n = 344) | P |
|---|---|---|---|---|
| Age (years, mean ± SD) | 34.22 ± 4.9 | 34.06 ± 4.9 | 34.55 ± 4.9 | 0.14 |
| Gestations (number, mean ± SD) | 2.97 ± 1.2 | 2.89 ± 1.1 | 3.14 ± 1.3 | 0.001 |
| Deliveries (number, mean ± SD) | 0.22 ± 0.4 | 0.17 ± 0.4 | 0.41 ± 0.6 | <0.001 |
| Miscarriages (number, mean ± SD) | 2.71 ± 1.0 | 2.71 ± 0.9 | 2.72 ± 1.1 | 0.99 |
| Primary RM, n (%) | 857 (78.2) | 636 (84.6) | 221 (64.2) | <0.001 |
|
Genetic factor, n (%) Primary RM, n |
68 (6.2) 53 |
50 (6.6) 39 |
18 (5.2) 14 |
0.37 |
|
Anatomic factor, n (%) Primary RM, n |
27 (2.5) 21 |
16 (2.1) 13 |
11 (3.2) 8 |
0.29 |
|
Immune category 1, n (%) Primary RM, n |
668 (60.9) 527 |
426 (56.6) 370 |
242 (70.3) 157 |
<0.001 |
|
Immune category 2, n (%) Primary RM, n |
219 (20.0) 169 |
167 (22.2) 139 |
52 (15.5) 30 |
0.006 |
|
Immune category 3, n (%) Primary RM, n |
138 (12.6) 105 |
108 (14.,4) 87 |
30 (8.7) 18 |
0.009 |
|
Immune category 4, n (%) Primary RM, n |
71 (6.5) 56 |
51 (6.8) 40 |
20 (5.8) 16 |
0.54 |
P < 0.05 was considered statistically significant, using Student’s t-test or Kruskal–Wallis test for numerical variables and Fisher’s exact-test or χ2 test when appropriate for categorical variables. LIT: lymphocyte immunotherapy. RM: recurrent miscarriage. SD, Standard deviation; n, number. Category 1: alloimmune factor positive; Category 2: alloimmune factor and thrombophilic factor: at least one positive test for thrombophilia (antiphospholipid syndrome and/or other hereditary thrombophilias with positive heterozygotic or homozygotic status); Category 3: alloimmune factor and autoimmune factor (at least one positive autoantibody, except patients with APS who were allocated to category 2. Category 4: alloimmune factor associated with at least one thrombophilia and at least one autoantibody.